Brian Duffy contributed to four key space shuttle missions, logging over 975 hours in space, and played a vital role in expanding the International Space Station (ISS).

Brian Duffy’s first flight was in 1992 as pilot of space shuttle Atlantis (STS-45), carrying the ATLAS-1 mission to study the atmosphere and solar interactions. On space shuttle Endeavor (STS-57) in 1993, Duffy piloted the first flight of the commercial SPACEHAB, which doubled the pressurized workspace for experiments on the ISS and included a spacewalk and the retrieval of the European Retrievable Carrier.

As commander of STS-72 in 1996, Duffy led the retrieval of the Space Flyer Unit and tested techniques for future space station assembly. His leadership continued as commander of STS-92, where the crew helped expand the ISS by attaching the Z1 Truss and Pressurized Mating Adapter 3, laying the foundation for future assembly missions.

Duffy also served as spacecraft communicator (CAPCOM) for Mission Control and as Assistant Director and Deputy Director at NASA’s Johnson Space Center. After retiring from NASA and the Air Force in 2001, he served as Vice President at Lockheed Martin. As of January 2025, he currently serves as Vice President for Exploration Systems at Orbital ATK.